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Clinical and Basic Research

  • I. CLINICAL STUDIES
    • A. Clinical Trials/Sponsored
      • ERICH (Ethnic and Racial variations in ICH)
      • ATACH II (Antihypertensive Treatment of Acute Cerebral Hemorrhage: Phase III randomized multicenter clinical trial of blood pressure reduction for hypertension in acute intracerebral hemorrhage)
      • EDGE (Phase 1/2a multicenter, controlled, randomized, open-label, dose escalation, safety, tolerability and pharmacokinetic study comparing EG-1962 and nimodipine in patients with aneurysmal subarachnoid hemorrhage)
      • MISTIE III (Minimally Invasive Surgery plus rt-PA for ICH Evacuation Phase III)
      • K2M (Comparison of complication rates between lateral approaches to the lumbar spine)
      • N2QOD-Database for neurosurgical clinical procedures.
      • MINISEND (Minimally Invasive Selective Endoscopic Discectomy with Annular Thermoplasty) versus sham and conservative care: a prospective randomized study
      • CSF proteomics biomarkers screening in traumatic brain injury
    • B. HUD (Humanitarian Use Devices) Interventional Radiology
      • Wingspan
      • Onyx
      • Enterprise
      • Neuroform/NeuroformEZ Stent
      • LVIS & LVIS Jr
    • C. Departmental Investigator-Initiated Studies
      • Multimodal neuromonitoring for brain-monitored variable cross-correlation and outcome prediction including App development for use with the CNS monitor.
      • Blood-brain barrier permeability and hemorrhagic transformation in acute ischemic stroke by quantitative blood-brain barrier measurement by CTP.
      • Hemorrhagic progression of a contusion: prediction by quantitative blood brain barrier measurement by CTP.
      • Spreading depression in traumatic brain injury and cerebrovascular accidents
      • Biomarker validation in mild traumatic brain injury
      • Multimodal monitoring and brain monitoring cross-correlations and outcome prediction.
      • Cerebral perfusion pressure and control of intracranial pressure.
      • Pulsed electromagnetic field treatment for traumatic brain injury and cerebrovascular accidents.
      • Speckle monitoring of intraoperative spreading depression.
      • SDF-1 in the pathogenesis of recurrent subdural hematomas.
      • Endogenous opioids in the placebo effects in back pain.
      • SEPS – a retrospective study of outcomes following subdural evacuation port system, compared with burr hole placement and craniotomy for the treatment of chronic SDH.
      • Intraoperative recording of cortical spreading depression. Cerebral arteriovenous malformations – a multi-site, retrospective chart review of management and treatment outcomes of cerebral AVM's.
      • PET 15O2 measurement of white matter hyperintensities in relation to mild cognitive impairment, vascular dementia, Alzheimer’s disease, multiple sclerosis, lupus and metabolic syndrome.
      • PET O15 regional brain oxygen metabolism and blood flow in aging, metabolic syndrome and stroke.
    • D. Exempt Studies
      • Retrospective study of clinical course and outcome in aneurysmal patients with and without ventriculosternostomy after SAH
      • Intraoperative radiation exposure Interobserver CSD scoring
  • II. LABORATORY RESEARCH
    • Stroke
      • Micro RNA inhibition in improving recovery from stroke.
      • Stroke treatment by drag-reducing polymer modulation of cerebral blood flow.
      • Improvement of cerebral blood flow in hypertensive encephalopathy by drag- reducing polymer.
      • Drag-reducing polymer improvement of cerebral blood flow after acute ischemic stroke.
      • Beta agonist in the treatment of acute ischemic stroke.
      • Peptide treatment for acute ischemic stroke.
      • Microvascular shunting in response to high ICP and relationship to the loss of CBF autoregulation.
      • Isoxsuprine treatment for ischemic stroke.
    • Traumatic Brain Injury
      • Drag-reducing polymer improvement of cerebral blood flow after traumatic brain injury.
      • Assessment of recoverability from ischemic stroke and traumatic brain injury by voxel analysis of cerebral blood flow and cerebral arteriovenous oxygen, lactate and glucose difference.
      • Post-traumatic stress disorder after traumatic brain injury.
      • Ischemic brain injury suffered as a result of high ICP-induced microvascular shunting.
      • Microvascular shunting and the link to the loss of cerebral blood flow autoregulation.
      • Pathogenesis of repetitive mild traumatic brain injury
      • Pulsed electromagnetic field in the treatment of traumatic brain injury.
      • Interference of cross-frequency coupling by cortical spreading depression.
    • Multiple Sclerosis
      • Peptide therapy for the treatment of multiple sclerosis in a rat model.
      • White matter injury in multiple sclerosis.